DEVELOPMENT AND IN VITRO EX VIVO CHARACTERIZATION OF TRANSDERMAL FILMS CONTAINING VERAPAMIL HCL
Charushila Pisal* , Shekhar Holkar, Avinash Tekade, Manohar Patil
Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune-411033, Maharashtra.
The aim of this study was to design Verapamil HCL loaded matrix forming films for delivery via the transdermal route with the aim to enhance sustained release action of the drug and investigate their permeation potential through the skin. The films were prepared by solvent casting technique using Cassia fistula (CF)as a matrix forming polymer, Dibutyl phthalate (DBT) as plasticizer. Lemongrass oil and Walnut oil were incorporated as penetration enhancers. The films were evaluated for Thickness uniformity, weight variation, folding endurance, tensile strength measurement, drug content and in vitro and ex vivo diffusion study. In vitro and ex vivo permeation studies of formulation were performed using Franz diffusion cells. Formulation prepared with hydrophilic polymer containing permeation enhancer showed increased in vitro skin permeation as compared to all other formulations. When comparing Walnut oil and Lemongrass oil, Walnut oil shows better permeation profile compared to Lemongrass oil. By 32 full factorial design, 9 batches were prepared using walnut oil as a penetration enhancer, out of which the formulation F1 showed best physicochemical profile along with better mechanical strength of film. The ex vivo study shows 1.28 fold increase in penetration enhancement of the drug as compared to formulation without permeation enhancer. A3 (without penetration enhancer) and F1 (with penetration enhancer) films shows drug diffusion of 59.32 ±1.06% and 76.17 ±0.77 respectively.
DEVELOPMENT AND EVALUATION OF NANOEMULGEL FOR MEFENAMIC ACID
Vaibhav Changediya (1) ,Rupalben Jani (2)
1 Department of Pharmaceutics, Parul Institute of Pharmacy And Research, Parul University, Vadodara, Gujarat, India.
2 Department of Pharmaceutics, Parul Institute of Pharmacy And Research, Parul University, Vadodara, Gujarat, India.
The present work is aimed to formulation and evaluation of nanoemulgel of mefenamic acid for improving its efficacy, stability, and permeability, bioavailability for the treatment of arthritis. O/W Nanoemulsions were prepared using Spontaneous emulsification method. Capmul oil was chosen as the oil phase, Tween 80, Polyethylene glycol 400 were used as surfactant and cosurfactant respectively, on the basis of solubility studies and emulsification studies in the formulation of nanoemulsion. Further optimized nanoemulgel was incorporated into different concentration of Carbopol-980 to get a gel for improving convenience in superficial application of the drug. Drug loaded nanoemulsions and nanoemulgel were characterized for particle size, viscosity, rheological behavior, thermodynamic stability studies. The optimized formulation was compared to conventional gel formulation and it showed higher permeation rate in-vitro which justifies the nanoemulgel to be a promising carrier for transdermal delivery of mefenamic acid. The optimized formulation showed higher drug release of 90.4%, compared to conventional gel that released 60.2% release in about 9 hrs. The study suggested that nanoemulgel significantly enhanced bioavailability of transdermally applied mefenamic acid .
ANALGESIC SUBCUTANEOUS IMPLANTS FOR CHRONIC PAIN MANAGEMENT USING HOT MELT EXTRUSION TECHNOLOGY
Akash Lingayat*, Purnima Amin
Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Matunga, Mumbai 400019
Conventional drug delivery for chronic pain management becomes difficult due to multiple doses. The sustained release dosage form reduces dosing frequency and increases compliance. Implant dosage form has supervision-free, prolonged and sustained delivery of active ingredients at desired therapeutic levels for ensuring comfort, relieving pain, and treatment of physiological conditions without any toxicity. The implants were prepared using Hot Melt Extrusion (HME) Technology. They were extruded in the form of cylindrical rods, which, can be inserted by syringe or surgery. The HME forms a polymer matrix in which the drug is uniformly distributed. Thus, selection of polymer becomes critical, as there should be no interaction between the polymer and the drug. Pharmaceutical grade polymers were used for making implants, which are approved by the regulatory authorities. Property of drug, polymer and the type of polymer matrix formed determines the release rate of the drug. The drug release from the implant exhibited zero order kinetics. The pharmacokinetic study of the implants in wistar rats suggested maintenance of steady state dose of 1ng/ml until 21 days. An IVIVC correlation was established with a regression coefficient value of 0.98.
Generation of 3D-printed multi-functional customized drug delivery system: In-vitro and In-vivo evaluations
Purushottam Suryavanshi*, Subham Banerjee
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Guwahati, Changsari-781101, Kamrup, Assam, India.
Stereolithography (SLA) assisted 3D-Printed Microneedles for Rifampicin Skin Delivery
Vivek Yadav*, Subham Banerjee.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Changsari-781101, Kamrup, Assam, India.